Thilo Enderle Ph.D.


Head of Discovery

Dr. Thilo Enderle joined E-Scape Bio with 20 years of experience in early drug discovery towards small and large molecule therapeutics, and currently works with the company as a consultant. Most recently he was Senior Leader at Pharma Research and Early Development of F. Hoffmann – La Roche Ltd where he led an interdisciplinary and multicultural team in a global matrix organization.

With the team, he has been driving projects for a large variety of disease areas (Neuroscience, Ophthalmology, Virology, Inflammation, Oncology and Cardiovascular and Metabolic Diseases) from target assessment through lead identification and lead optimization. He was responsible for the development of more than 250 different in-vitro assays in more than 100 programs and their implementation on automation platforms, biochemical and cell-based assays of all target classes as well as phenotypic readouts. Several of the lead compounds which were generated by Dr. Enderle and his team reached late clinical stage and are still in active programs.

In his role as Global HTS coordinator of Roche he was the main contact to external academic partners and CRO's in Asia, Europe and US for collaborations and outsourcing of assay development and screening related activities. During his time at Roche he set up several technology platforms with multi-site impact such as the global implementation of ultra-HTS systems at 7 research sites, the formation of a global assay method development group and a platform for phenotypic and stem-cell based assays and screening. He filed 11 patent applications for proprietary assay methods and automation solutions, three of his inventions were commercialized. Dr Enderle graduated from the University of Basel in Experimental Physics and Non-Linear Optics. He gained several fellowships from the Swiss National Science Foundation and Ciba-Geigy Foundation. Prior to joining Roche, he was a Research Fellow in Biophysics at the Molecular Design Institute of Lawrence Berkeley National Laboratory for 3 years.